DOUXO Calm Shampoo is a soothing lathering solution that contains hinokitiol and phytosphingosine. It?s a topical treatment of allergy and pruritus. This calming pet shampoo makes bath time for dogs and cats more enjoyable. Directions: wet your pet with warm water and apply on the coat and lather freely. Avoid contact with the eyes and mouth. Don?t allow ingestion. Leave on for 5-10 minutes before rinsing. The veterinarian?s recommendations should be observed. Generally recommended to use 2-3 times a week for the first 1-2 weeks.