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COMFORTIS Green is for dogs 20.1-40 lbs.; the medication can be used on puppies 14 weeks of age and older. Comfortis chewable tablets kill fleas and prevent infestations (Ctenocephalides felis) on dogs for one month.COMFORTIS chewable tablets (spinosad) are given orally once a month, at the recommended minimum dosage of 13.5 mg/lb (30 mg/kg) and starts to work in 30 minutes. For maximum effectiveness, administer with food. Fast acting - starts killing fleas in 30 minutes. Kills fleas before they can lay eggs. Give with meals. Kills 100% of fleas within 4 hours Once a month application. A prescription isrequired for these products. Click here for details