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This double strength formulation is intended for larger dogs 25 lbs and over.Recommendation as a Supplement The Initial Administration Period is 6 Weeks. Most animals should respond within this period. Improvement on Cosequin can range from gradual to dramatic. If the improvement is gradual, it may go unnoticed by the owner. It is therefore important to keep the animal at the initial amount for at least 6 weeks before deciding to discontinue the use of Cosequin. If there is gradual improvement and Cosequin is discontinued, a regression of clinical status can occur.Effective alternative available for only $29.99 (120 Tablets)--> [ More Information ] Each Cosequin DS Tablet Contains: Glucosamine HCL 500 mg Sodium Chondroitin Sulfate 400 mg Ascorbate (as Manganese Ascorbate) 33 mg Manganese (Ascorbate) 5 mg