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Frontline Top Spot Blue for dogs and puppies provides flea and tick protection for at least one month. It is applied topically and each packet has 12 applications providing 12 months of protection. Effective Flea & Tick Control . . . No Prescription Required!Guaranteed US EPA approved. Over-The-Counter topical kills fleas & ticks in under 48 hours Protect against Lyme Disease! Easy to apply monthly preventive